Trans-1,2-diaminocyclohexane

CAS 1121-22-8

HS 2942000000

Product name: Trans-1,2-diaminocyclohexane
CAS No.: 1121-22-8
Molecular formula: C6H14N2
Applications:
Core Industrial Applications
1. Third-generation platinum anticancer drug oxaliplatin dedicated core intermediate (largest essential demand)
Full synthesis chain: (R,R)-trans-1,2-cyclohexanediamine → dichloroplatinum complex → oxalate displacement → oxaliplatin API. Oxaliplatin for colorectal and ovarian cancer — only (R,R) chiral scaffold has anticancer activity; irreplaceable feedstock.
2. Asymmetric catalysis chiral ligands
1. C2-symmetric Schiff bases and phosphinamide chiral ligands for Suzuki, hydrogenation and epoxidation asymmetric catalysis;
2. Metal-catalyzed extraction and chiral chromatography stationary-phase resolving agents.
3. High-end epoxy resin curing agents
Cyclic diamine thermal stability far superior to aliphatic chain diamines; cured films resist acid/alkali with low yellowing — anti-corrosion flooring, electronic potting, metal primers.
4. Other fine chemicals
1. Lubricant and pipeline acid-pickling corrosion inhibitors adsorbing on metal to form protective film;
2. Specialty surfactants and polyamide resin modification monomers;
3. Peptide synthesis and heterocyclic drug chiral scaffolds.

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