(S)-2-Benzylsuccinic acid

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CAS 3972-36-9

HS 2917399090

Product name: (S)-2-Benzylsuccinic acid
CAS No.: 3972-36-9
Molecular formula: C11H12O4
Applications:
Core Industrial Applications (diabetes API core chiral intermediate)
1. Mitiglinide calcium dedicated upstream feedstock (~95% consumption)
Full synthesis chain: S-2-benzylsuccinic acid → monoester reduction → chiral alcohol intermediate → condensation to mitiglinide calcium API. Mitiglinide is short-acting insulin-secretagogue antidiabetic — only S configuration has drug activity; R configuration inactive — irreplaceable chiral building block.
2. Pharmaceutical extension applications
1. Metalloenzyme inhibitor R&D feedstock: carboxypeptidase A and metallo-β-lactamase inhibitors;
2. Chiral drug resolving agent and peptide synthesis chiral scaffold;
3. Drug impurity reference standard calibration material.
3. Fine organic synthesis
Dibasic acid monomer for chiral polyesters and polyamides; Schiff-base metal coordination ligand synthesis.

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