Propanoyl chloride

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CAS 79-03-8

HS 2915900090

Product name: Propanoyl chloride
CAS No.: 79-03-8
Molecular formula: C3H5ClO
Applications:
Core Industrial Applications
1. Pharmaceutical intermediates (largest use)
Synthesis of cephalosporin, ibuprofen-type anti-inflammatory and CNS drug side chains; acylation reagent for peptides and heterocyclic APIs; Friedel–Crafts preparation of aromatic drug scaffolds.
2. Agrochemicals
Intermediate for herbicides, fungicides and organophosphorus insecticides; propionyl group modulates pesticide systemicity.
3. Fragrances
Synthesis of propionate fruit fragrances (ethyl propionate, isobutyl propionate) for berry and wine-type accords.
4. Organic synthesis / polymer additives
General Friedel–Crafts acylation reagent; preparation of tert-butyl peroxypropionate polymerization initiator; amide-type surfactant synthesis.
VI. Storage & Handling
1. Store in a Class A explosion-proof cool warehouse; keep sealed under nitrogen, protected from light and moisture
2. Segregate from water, alcohols, amines, alkalis, strong oxidizers and reactive metals (Fe/Al)
3. Ground equipment against static; use non-sparking tools; no open charging
4. Typical pack: industrial 200 kg PE-lined steel drums; reagent brown pressure bottles
5. Shelf life typically 12 months sealed anhydrous; open storage rapidly h

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