Oxalyl chloride

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CAS 79-37-8

HS 2942000000

Product name: Oxalyl chloride
CAS No.: 79-37-8
Molecular formula: C2Cl2O2
Applications:
Core Industrial / Laboratory Applications
1. General acyl-chlorination agent for organic synthesis (largest use)
Converts aromatic, aliphatic and heterocyclic carboxylic acids to acyl chlorides; downstream coverage includes pharmaceuticals, pesticides and dyes; compared with thionyl chloride, no sulfur dioxide residue; more compatible with sensitive substrates.
2. Dedicated Swern oxidation reagent
Low-temperature (−78 °C) oxidation of primary and secondary alcohols without over-oxidation; widely used in chiral drug and natural product synthesis without destroying chiral centers.
3. Pharmaceutical heterocycle intermediate synthesis
Diacyl chloride used for pyrimidine, imidazole, indole and other heterocycle ring closures; key building block for antibiotic, antitumor and antidepressant APIs.
4. GC derivatization reagent and polymer crosslinker
• Micro-scale hydroxyl and amino sample derivatization to enhance chromatographic detection sensitivity
• Low-temperature crosslink modification of polyurethane and polyamide resins to improve coating solvent resistance
5. Pesticide and liquid-crystal material intermediates
Heterocyclic herbicide and liquid-crystal aromatic backbone acylation m

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