malonoyl chloride

Name: Shanghai Blue Aurora Fine Chemical Technology Co., Ltd.
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CAS 1663-67-8

HS 2917190090

Product name: malonoyl chloride
CAS No.: 1663-67-8
Molecular formula: C3H2Cl2O2
Applications:
Core Industrial Applications
1. Sulfonamide antibiotic pharmaceutical intermediates (largest demand)
Synthesis of sulfathiazole, sulfisoxazole, sulfamethoxazole, sulfaphenazole and other broad-spectrum antibacterials; diacyl chloride ring closure builds oxazole and thiazole five-membered heterocycle scaffolds.
2. Heterocyclic drugs and fine APIs
• Ring-closure feedstock for quinoline, pyrimidine, pyrrole and coumarin anti-inflammatory, antifungal and antitumor drugs
• β-Diketone and β-keto ester synthesis building blocks for chiral drug intermediate condensation reactions
3. Dye and optical brightener intermediates
Difunctional symmetric acylation for bis-azo dyes and coumarin fluorescent dyes; enhances lightfastness and molecular conjugation.
4. Dedicated organic synthesis crosslinking reagent
• Bifunctional linker in peptide synthesis for crosslinking proteins and amino resins
• Polymer modification: polyamide and polyurethane chain extender; improves resin adhesion and solvent resistance
5. Analytical chemistry derivatization reagent
Quantitative derivatization of trace diols and diamines for GC/LC detection as dedicated acylation reagent

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